Mechanism of Action and Use of Radiomimetic Compounds

doi: 10.32567/hm.2022.1.7


Radiomimetic substances are drugs producing similar symptoms in living organisms as ionising radiation does.  They constitute a special subgroup of carcinogen, mutagen, teratogen compounds; their common characteristic is to  cause DNA breaks and/or to inhibit their repair. Mustard  gas and its derivatives – alkylating agents – were the first  known group of radiomimetic substances, later, it was  observed, that some purine and pyrimidine analogues  playing an antimetabolic role show a resembling outcome.  Initially mustards were used in warfare, but now their  usage for military purpose is prohibited by the Chemical  Weapons Convention. Other radiomimetic substances have  also become important tools in medicine, as they have  been shown to be useful against certain pathogens and  tumours. This review is a brief summary about the  mechanism of action and the most common applications of  alkylating agents and antimetabolites. In the coming second part, the radiomimetic substances of bacterial  origin are reviewed from similar perspectives. 


alkylating agents antimetabolites dicentric chromosome radiomimetic substances

Hogyan kell idézni

Deli, G. (2022). Mechanism of Action and Use of Radiomimetic Compounds. Hadmérnök, 17(1), 101–115.


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